Anisomycin

Anisomycin is a pyrrolidine antibiotic, which inhibits protein synthesis. It is produced by Streptomyces griseolus. Anisomycin is a potent activator of the Stress-activated protein kinases (SAPKs) and p38 mitogen-activated protein kinase (p38 MAPK), and is often used in scientific research to activate these pathways.

Mechanism of Action

Anisomycin interferes with protein synthesis by binding to the 60S subunit of the ribosome, which inhibits peptidyl transferase activity and results in the misreading of mRNA. This leads to the production of non-functional or toxic peptides, which can cause cell death.

Uses in Research

Anisomycin is commonly used in biological research to inhibit protein synthesis in eukaryotic cells. It is also used to study the role of protein synthesis in various cellular processes, such as cell growth, differentiation, and apoptosis. In addition, anisomycin is used to activate stress-activated protein kinases and p38 MAPK, which are involved in cellular responses to stress.

Side Effects

As an antibiotic, anisomycin can have side effects, including allergic reactions and toxicity. It is not used clinically due to its high toxicity.

See Also

• Protein synthesis
• Stress-activated protein kinases
• p38 mitogen-activated protein kinase
• Ribosome
• Peptidyl transferase

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