Ankyloblepharon filiforme adnatum
Ankyloblepharon Filiforme Adnatum Ankyloblepharon Filiforme Adnatum (AFA) is a rare congenital condition characterized by the partial or complete fusion of the eyelid margins. This condition is present at birth and can affect one or both eyes. The fusion is typically due to thin bands of tissue that connect the upper and lower eyelids.
Presentation[edit | edit source]
AFA is usually identified at birth during a routine physical examination. The condition is marked by the presence of eyelid adhesions, which can vary in number and thickness. These adhesions can restrict the opening of the eyes, potentially affecting vision if not treated.
Etiology[edit | edit source]
The exact cause of Ankyloblepharon Filiforme Adnatum is not well understood. It is believed to result from developmental anomalies during embryogenesis. AFA can occur as an isolated condition or as part of a syndrome, such as Hay-Wells syndrome (also known as AEC syndrome), which involves other ectodermal dysplasias.
Diagnosis[edit | edit source]
Diagnosis of AFA is primarily clinical, based on the observation of the characteristic eyelid adhesions. In some cases, additional diagnostic procedures may be performed to rule out associated syndromes or anomalies. Genetic testing may be considered if a syndromic association is suspected.
Treatment[edit | edit source]
The treatment of Ankyloblepharon Filiforme Adnatum typically involves surgical intervention to separate the fused eyelids. This procedure is usually straightforward and can be performed shortly after birth to prevent any potential impact on vision development. Post-surgical care is important to ensure proper healing and to prevent recurrence.
Prognosis[edit | edit source]
The prognosis for individuals with isolated AFA is generally excellent following surgical correction. When AFA is part of a syndrome, the overall prognosis depends on the associated conditions and their management.
See Also[edit | edit source]
External Links[edit | edit source]
- [MedlinePlus: Eyelid Disorders](https://medlineplus.gov/eyeliddisorders.html)
- Genetic and Rare Diseases Information Center (GARD)
NIH genetic and rare disease info[edit source]
Ankyloblepharon filiforme adnatum is a rare disease.
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