Antifibrinolytics

Antifibrinolytics are a class of medication that are used to reduce bleeding in certain situations such as heavy menstrual bleeding, nosebleeds, tooth extraction, and in high-risk surgeries. They work by inhibiting the breakdown of fibrin, which is a protein that forms blood clots.

Mechanism of action

Antifibrinolytics work by inhibiting the action of plasmin, an enzyme that breaks down fibrin. This results in the stabilization of formed blood clots, reducing the amount of bleeding.

Types

There are several types of antifibrinolytics, including:

• Aminocaproic acid
• Tranexamic acid
• Aprotinin

Uses

Antifibrinolytics are used in a variety of situations to reduce bleeding. These include:

• Menorrhagia (heavy menstrual bleeding)
• Epistaxis (nosebleeds)
• Tooth extraction
• High-risk surgeries such as cardiac surgery and orthopedic surgery

Side effects

Like all medications, antifibrinolytics can have side effects. These can include:

• Nausea
• Diarrhea
• Muscle weakness
• Headache
• Hypotension (low blood pressure)

See also

• Coagulation
• Hemostasis
• Fibrinolysis

Antifibrinolytics Resources
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