Antipyrine
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Antipyrine is an analgesic and antipyretic drug, which was once widely used to reduce pain and fever. Antipyrine is often used in combination with other substances to enhance its effects. It is known chemically as 1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one.
History[edit | edit source]
Antipyrine was first synthesized by Ludwig Knorr in 1883 as part of his quest to find a safer alternative to the quinine and salicylates used at the time. The drug quickly became popular due to its effectiveness in reducing pain and fever.
Pharmacology[edit | edit source]
The mechanism of action of antipyrine is not fully understood, but it is thought to work by inhibiting the synthesis of prostaglandins, which are chemicals in the body that promote inflammation, pain, and fever. Antipyrine is known to have analgesic and antipyretic effects, which help in relieving pain and reducing fever respectively.
Medical uses[edit | edit source]
Antipyrine is used to treat mild to moderate pain and to reduce fever. It has also been used in the past as an ingredient in various ear drops for the treatment of ear pain and inflammation.
Side effects[edit | edit source]
Like all medications, antipyrine can cause side effects. Common side effects include gastrointestinal disturbances such as nausea and vomiting, as well as allergic reactions. Due to its side effects and the development of newer drugs with fewer adverse effects, the use of antipyrine has declined over time.
Regulation[edit | edit source]
The legal status and availability of antipyrine can vary by country, with some places requiring a prescription for its use, while in others it may be available over the counter.
See also[edit | edit source]
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