Antisperm antibodies

Antisperm antibodies are immune system proteins that mistakenly identify sperm as harmful invaders and attempt to eliminate them. These antibodies can bind to various parts of the sperm, such as the head or tail, potentially affecting the sperm's ability to move and to fertilize an egg. The presence of antisperm antibodies in either men or women can be a significant factor in infertility.

Causes

Antisperm antibodies are most commonly found in men following a breach in the barrier between the blood and the testes, which normally prevents the immune system from recognizing sperm as foreign. This can occur due to injury, surgery (such as a vasectomy), infection, or other conditions that cause inflammation of the testes. In women, antisperm antibodies may form if the immune system is exposed to sperm through intercourse, but this is less common.

Diagnosis

The diagnosis of antisperm antibodies can be challenging. In men, the antibodies can be detected through a blood test, a semen analysis, or both. The Mar test or the immunobead test are specific tests used to detect these antibodies in semen or attached to the surface of sperm. In women, the presence of antisperm antibodies can be assessed through a blood test or cervical mucus testing.

Impact on Fertility

Antisperm antibodies can impair fertility in several ways. They may cause sperm to clump together, reducing motility and the ability to reach the egg. They can also interfere with the sperm's ability to penetrate the outer layer of the egg, necessary for fertilization. In some cases, these antibodies can even trigger the immune system to destroy the sperm.

Treatment

Treatment for antisperm antibodies varies depending on the underlying cause and the severity of the condition. For men, options may include taking medications to suppress the immune system, washing sperm to remove antibodies before intrauterine insemination (IUI) or in vitro fertilization (IVF), and using assisted reproductive technologies (ART) that bypass natural fertilization barriers, such as intracytoplasmic sperm injection (ICSI). For women with antisperm antibodies, treatment may focus on techniques to bypass the cervical mucus, such as IUI or IVF.

Prevention

Preventing the formation of antisperm antibodies involves avoiding known risk factors, such as unnecessary testicular injuries and surgeries. Early treatment of infections or conditions that may lead to testicular inflammation can also reduce risk.

See Also

• Infertility
• Immune system
• Sperm
• Testes
• Vasectomy
• Intrauterine insemination (IUI)
• In vitro fertilization (IVF)
• Intracytoplasmic sperm injection (ICSI)

Resources

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Antisperm antibodies for any updates.

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