Antistreptolysin
Antistreptolysin
Antistreptolysin is an antibody produced by the immune system in response to an infection with group A Streptococcus bacteria. These bacteria produce an enzyme called streptolysin O, which is capable of lysing red blood cells and is considered a virulence factor. The presence of antistreptolysin antibodies in the blood is used as a marker for recent streptococcal infection.
Biological Role[edit | edit source]
Antistreptolysin antibodies are part of the body's immune response to infection. When group A Streptococcus bacteria infect the body, they release streptolysin O, which can damage host tissues. The immune system responds by producing antistreptolysin antibodies to neutralize the effects of streptolysin O.
Clinical Significance[edit | edit source]
The measurement of antistreptolysin O (ASO) titers is a common laboratory test used to determine if a person has had a recent streptococcal infection. Elevated ASO titers can indicate a recent infection and are often used in the diagnosis of conditions such as rheumatic fever and post-streptococcal glomerulonephritis.
ASO Titer Test[edit | edit source]
The ASO titer test measures the level of antistreptolysin antibodies in the blood. A high ASO titer suggests a recent streptococcal infection. However, it is important to note that not all individuals with a streptococcal infection will have elevated ASO titers, and elevated titers can persist for several months after the infection has resolved.
Interpretation of Results[edit | edit source]
- Normal Range: The normal range for ASO titers can vary depending on the laboratory, but generally, a titer of less than 200 units/mL is considered normal in adults. - Elevated ASO Titers: Elevated ASO titers may indicate a recent streptococcal infection. In the context of clinical symptoms, elevated titers can support the diagnosis of rheumatic fever or post-streptococcal glomerulonephritis.
Limitations[edit | edit source]
The ASO titer test has limitations. It does not indicate the site of infection or the severity of the disease. Additionally, some individuals may not produce a significant antibody response, leading to false-negative results.
Also see[edit | edit source]
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