Apatinib
Overview[edit | edit source]
Apatinib is a small molecule tyrosine kinase inhibitor that selectively targets the vascular endothelial growth factor receptor-2 (VEGFR-2). It is primarily used in the treatment of various types of cancer, particularly gastric cancer and colorectal cancer. Apatinib works by inhibiting angiogenesis, the process by which new blood vessels form from pre-existing vessels, which is crucial for tumor growth and metastasis.
Mechanism of Action[edit | edit source]
Apatinib exerts its effects by binding to the intracellular domain of VEGFR-2, thereby blocking the downstream signaling pathways that promote endothelial cell proliferation and migration. This inhibition leads to reduced tumor vascularization and, consequently, tumor growth suppression.
Clinical Applications[edit | edit source]
Apatinib has been studied extensively in clinical trials for its efficacy in treating advanced gastric cancer and other malignancies. It is often considered for patients who have not responded to standard chemotherapy regimens. The drug has shown promise in improving progression-free survival and overall survival in certain patient populations.
Side Effects[edit | edit source]
Common side effects of apatinib include hypertension, proteinuria, hand-foot syndrome, and fatigue. These adverse effects are generally manageable with supportive care and dose adjustments.
Research and Development[edit | edit source]
Ongoing research is exploring the potential of apatinib in combination with other therapeutic agents, such as immunotherapy and chemotherapy, to enhance its anticancer effects. Studies are also investigating its role in treating other types of cancer, including non-small cell lung cancer and breast cancer.
Related Pages[edit | edit source]
Gallery[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
