Apramycin
An aminoglycoside antibiotic used in veterinary medicine
Apramycin[edit | edit source]
Apramycin is an aminoglycoside antibiotic primarily used in veterinary medicine. It is effective against a range of Gram-negative bacteria and is commonly used to treat infections in animals such as pigs, cattle, and poultry.
Mechanism of Action[edit | edit source]
Apramycin works by binding to the bacterial ribosome, specifically the 30S subunit, which inhibits protein synthesis. This action is similar to other aminoglycosides, leading to the disruption of bacterial cell function and ultimately causing cell death. The antibiotic is particularly effective against bacteria that are resistant to other aminoglycosides due to its unique structure.
Uses in Veterinary Medicine[edit | edit source]
Apramycin is used to treat a variety of bacterial infections in animals. It is often administered to young animals to prevent and treat enteric infections caused by susceptible bacteria. The drug is available in several formulations, including oral solutions and feed additives, making it versatile for different types of livestock management.
Pharmacokinetics[edit | edit source]
After administration, apramycin is absorbed into the bloodstream and distributed throughout the body. It is primarily excreted unchanged in the urine, which is typical for aminoglycosides. The drug's pharmacokinetic properties can vary depending on the species and age of the animal, as well as the route of administration.
Resistance[edit | edit source]
Bacterial resistance to apramycin can occur, although it is less common compared to other aminoglycosides. Resistance mechanisms include modification of the antibiotic by bacterial enzymes, changes in the ribosomal binding site, and efflux pumps that remove the drug from the bacterial cell. Monitoring and prudent use of apramycin are essential to minimize the development of resistance.
Safety and Toxicity[edit | edit source]
Apramycin is generally well-tolerated in animals when used at recommended doses. However, like other aminoglycosides, it can cause nephrotoxicity and ototoxicity at high doses or with prolonged use. Careful dosing and monitoring are important to prevent these adverse effects.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
