Aquaporin-8

Aquaporin-8 (AQP8) is a protein that in humans is encoded by the AQP8 gene. It is a member of the aquaporin family of water channels that are primarily responsible for water transport across cell membranes.

Function

Aquaporin-8 is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes a protein that functions as a molecular water channel protein. It is found in many tissues and has a wide variety of functions. These include facilitating the transport of water across cell membranes, increasing the permeability of the skin and mucous membranes to water, and playing a role in the secretion and absorption of water in the kidneys.

Structure

Aquaporin-8 is a transmembrane protein that forms a pore in the cell membrane. The protein is composed of six transmembrane domains, with the N- and C-termini located on the cytoplasmic side of the membrane. The protein forms a tetramer in the membrane, with each monomer functioning as an independent water channel.

Clinical significance

Mutations in the AQP8 gene have been associated with various diseases, including diabetes insipidus, nephrogenic diabetes insipidus, and congenital cataracts. Further research is needed to fully understand the role of AQP8 in these conditions.

See also

• Aquaporin
• Cell membrane
• Transmembrane protein

External links

• National Center for Biotechnology Information: AQP8 aquaporin 8 (human)