Ariadne (drug)

Ariadne is a pharmacological agent that is classified as a dopamine antagonist. It is primarily used in the treatment of psychotic disorders, including schizophrenia and acute mania associated with bipolar disorder.

Pharmacology

Ariadne works by blocking dopamine receptors in the brain, specifically the D2 subtype. This reduces the overactivity of dopamine, which is thought to be a contributing factor in the development of psychotic symptoms. Ariadne also has some affinity for the D3 and D4 subtypes, but its clinical significance is less clear.

Clinical Use

Ariadne is used in the treatment of various psychotic disorders. It is most commonly used in the management of schizophrenia, where it can help to control symptoms such as hallucinations, delusions, and disorganized thinking. It may also be used in the treatment of acute mania associated with bipolar disorder, where it can help to control symptoms such as elevated mood, increased energy, and decreased need for sleep.

Side Effects

Like all medications, Ariadne can cause side effects. The most common side effects include drowsiness, dizziness, and dry mouth. Less common but more serious side effects can include movement disorders such as tardive dyskinesia, and metabolic changes such as weight gain and increased blood sugar levels.

Contraindications

Ariadne is contraindicated in individuals with a known hypersensitivity to the drug. It should also be used with caution in individuals with a history of cardiovascular disease, as it can cause changes in heart rate and blood pressure.

See Also

• Dopamine antagonist
• Psychosis
• Schizophrenia
• Bipolar disorder