Arrestin beta 2

Arrestin beta 2 (also known as β-arrestin 2 or ARRB2) is a protein that in humans is encoded by the ARRB2 gene. It is part of the arrestin family of proteins, which play a crucial role in regulating G protein-coupled receptor (GPCR) signaling.

Function

Arrestin beta 2 is a member of the arrestin/beta-arrestin protein family. This family plays a major role in regulating receptor-mediated intracellular signal transductions. Arrestin beta 2, like arrestin beta 1, was shown to inhibit G protein-coupled receptor kinase 2-mediated phosphorylation of the activated muscarinic receptor.

Clinical significance

Alterations in the ARRB2 gene have been associated with various diseases, including schizophrenia, bipolar disorder, and opioid dependence. Further research is needed to fully understand the role of arrestin beta 2 in these conditions.

Structure

The ARRB2 gene is located on the q arm of chromosome 17 at position 13.2 and it spans 25,789 base pairs. The ARRB2 gene produces a 46.1 kDa protein composed of 409 amino acids.

Interactions

Arrestin beta 2 has been shown to interact with various proteins, including:

• G protein-coupled receptor kinase 6
• G protein-coupled receptor kinase 2
• G protein-coupled receptor kinase 5
• G protein-coupled receptor kinase 3

See also

• Arrestin
• G protein-coupled receptor

References

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