Arteriviridae
Apraclonidine[edit | edit source]
Apraclonidine is a sympathomimetic drug used primarily in the field of ophthalmology. It is an alpha-2 adrenergic receptor agonist, which means it works by stimulating alpha-2 adrenergic receptors in the body. This medication is commonly used to reduce intraocular pressure (IOP) in patients with glaucoma or ocular hypertension.
Mechanism of Action[edit | edit source]
Apraclonidine works by decreasing the production of aqueous humor and increasing uveoscleral outflow, which helps to lower intraocular pressure. By stimulating alpha-2 adrenergic receptors, apraclonidine reduces the activity of the sympathetic nervous system, leading to decreased production of aqueous humor by the ciliary body in the eye.
Clinical Uses[edit | edit source]
Apraclonidine is primarily used in the management of glaucoma and to prevent or control spikes in intraocular pressure following certain types of eye surgery, such as laser trabeculoplasty or laser iridotomy. It is often used as a short-term adjunctive therapy in patients who are already on other IOP-lowering medications.
Administration[edit | edit source]
Apraclonidine is typically administered as an ophthalmic solution, with a common concentration being 0.5% for general use and 1% for short-term use in surgical settings. The medication is applied directly to the eye, usually one drop in the affected eye(s) two to three times a day, as directed by a healthcare provider.
Side Effects[edit | edit source]
Common side effects of apraclonidine include dry mouth, fatigue, and ocular discomfort. Some patients may experience allergic reactions, such as itching or redness of the eyes. Long-term use can lead to tachyphylaxis, where the drug becomes less effective over time.
Contraindications[edit | edit source]
Apraclonidine is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with severe cardiovascular disease, as systemic absorption can lead to cardiovascular effects.
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