Artesunate/mefloquine
Artesunate/mefloquine is a combination of two antimalarial medications, artesunate and mefloquine. It is used to treat malaria, a disease caused by parasites that enter the body through the bite of a mosquito.
Mechanism of Action[edit | edit source]
Artesunate works by producing free radicals within the malarial parasite, which kills it. Mefloquine, on the other hand, damages the parasite's DNA and interferes with its ability to reproduce.
Indications[edit | edit source]
Artesunate/mefloquine is indicated for the treatment of acute uncomplicated malaria infections due to Plasmodium falciparum in adults and children.
Contraindications[edit | edit source]
Artesunate/mefloquine is contraindicated in patients with known hypersensitivity to artesunate, mefloquine, or any component of the formulation. It is also contraindicated in patients with a history of psychiatric disorders or seizures.
Side Effects[edit | edit source]
Common side effects of artesunate/mefloquine include nausea, vomiting, diarrhea, abdominal pain, and dizziness. Serious side effects may include QT prolongation, severe allergic reactions, and neuropsychiatric effects.
Drug Interactions[edit | edit source]
Artesunate/mefloquine may interact with other medications, including antiretroviral drugs, antiepileptic drugs, and other antimalarial medications.
Dosage and Administration[edit | edit source]
The dosage of artesunate/mefloquine depends on the patient's weight. It is usually taken once a day for three days.
Precautions[edit | edit source]
Patients should be monitored for signs of hypersensitivity reactions and neuropsychiatric effects. Electrocardiogram (ECG) monitoring should be considered in patients with risk factors for QT prolongation.
Pregnancy and Lactation[edit | edit source]
Artesunate/mefloquine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether artesunate/mefloquine is excreted in human milk.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
