Atgam
Atgam is a medication used primarily in the treatment of acute rejection in organ transplantation and aplastic anemia. It is an immunosuppressive drug that contains antithymocyte globulin (ATG), which is derived from the serum of horses immunized with human thymocytes.
Medical Uses[edit | edit source]
Atgam is used to prevent and treat acute rejection in patients who have undergone kidney transplantation. It is also used in the management of moderate to severe aplastic anemia in patients who are not suitable candidates for bone marrow transplantation.
Mechanism of Action[edit | edit source]
Atgam works by targeting and depleting T cells, which are a type of white blood cell involved in the immune response. By reducing the number of T cells, Atgam helps to prevent the immune system from attacking the transplanted organ or the bone marrow.
Administration[edit | edit source]
Atgam is administered intravenously, typically over a period of several hours. The dosage and duration of treatment depend on the specific condition being treated and the patient's response to the medication.
Side Effects[edit | edit source]
Common side effects of Atgam include fever, chills, rash, and leukopenia. More serious side effects can include serum sickness, anaphylaxis, and increased risk of infections due to immunosuppression.
Precautions[edit | edit source]
Patients receiving Atgam should be monitored for signs of infection and other adverse reactions. It is important to use this medication under the supervision of a healthcare professional experienced in immunosuppressive therapy.
Related Pages[edit | edit source]
- Immunosuppressive drug
- Organ transplantation
- Aplastic anemia
- Bone marrow transplantation
- T cell
- White blood cell
- Leukopenia
- Serum sickness
- Anaphylaxis
- Infections
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Contributors: Prab R. Tumpati, MD
