Atosiban

Atosiban is an inhibitor that is used to halt preterm labor. It is a nonapeptide, synthetic oxytocin antagonist that inhibits the oxytocin receptor in the myometrium (uterine muscle).

Mechanism of Action[edit | edit source]

Atosiban works by competing with oxytocin for the oxytocin binding sites in the myometrium. This competition inhibits the action of oxytocin, which is responsible for uterine contractions. By blocking the action of oxytocin, Atosiban helps to stop premature labor.

Medical Uses[edit | edit source]

Atosiban is used to delay premature labor in pregnant women. It is typically used in women who are between 24 and 33 weeks pregnant, and who have a cervical dilation of less than 3 cm. Atosiban is administered as an intravenous infusion.

Side Effects[edit | edit source]

Common side effects of Atosiban include nausea, vomiting, and tachycardia. In rare cases, Atosiban can cause severe allergic reactions.

Contraindications[edit | edit source]

Atosiban should not be used in women with hypertension, preeclampsia, or other conditions that would make prolongation of pregnancy dangerous. It is also contraindicated in women with known hypersensitivity to the drug.

References[edit | edit source]

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Atosiban Resources
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