Atracurium

Atracurium is a medication used in anesthesia to induce muscle relaxation. It is a non-depolarizing neuromuscular-blocking drug (NMBD) and is administered intravenously. Atracurium is used to relax the muscles during surgery and other medical procedures.

Pharmacology

Atracurium works by blocking the action of acetylcholine, a neurotransmitter that transmits signals in the nervous system. By blocking acetylcholine, atracurium prevents the muscles from receiving signals to contract, thus causing muscle relaxation.

Clinical Use

Atracurium is used in a clinical setting, primarily during surgical procedures that require muscle relaxation. It is also used in intensive care units to facilitate ventilation and to manage patients with acute respiratory distress syndrome (ARDS).

Side Effects

Like all medications, atracurium can cause side effects. These may include flushing, skin rash, and bronchospasm. In rare cases, atracurium can cause severe allergic reactions.

History

Atracurium was first introduced in the 1980s as an alternative to succinylcholine for producing muscle relaxation during anesthesia. It has since become a commonly used drug in anesthesia and intensive care.

See Also

• Neuromuscular-blocking drug
• Anesthesia
• Acetylcholine