Augustine blood group system

Augustine blood group system is a blood group system that was discovered in 2015. It is named after the patient in which the first antigen, AUG(a), was identified. The system is recognized by the International Society of Blood Transfusion (ISBT) and is designated as system number 032.

History

The Augustine blood group system was discovered in 2015 by a team of researchers at the New York Blood Center. The first antigen, AUG(a), was identified in a patient named Augustine, hence the name of the system.

Antigens

The Augustine blood group system consists of two antigens, AUG(a) and AUG(b). These antigens are located on the erythrocyte membrane protein, SLC29A1, also known as the equilibrative nucleoside transporter 1 (ENT1). ENT1 is responsible for the transport of nucleosides across the cell membrane.

Clinical significance

The clinical significance of the Augustine blood group system is not yet fully understood. However, it is known that individuals who lack the AUG(a) antigen can produce antibodies against it if exposed through blood transfusion or pregnancy. This can potentially lead to hemolytic disease of the fetus and newborn (HDFN) or hemolytic transfusion reaction (HTR).

See also

• Blood group system
• Antigen
• Hemolytic disease of the fetus and newborn
• Hemolytic transfusion reaction

References

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