Aurotioprol

Aurotioprol

Aurotioprol is a gold compound used in the treatment of rheumatoid arthritis. It belongs to a class of drugs known as disease-modifying antirheumatic drugs (DMARDs), which are used to slow the progression of autoimmune diseases and reduce inflammation.

Mechanism of Action

Aurotioprol works by inhibiting the activity of certain immune system cells that contribute to the inflammatory process in rheumatoid arthritis. The exact mechanism of action is not fully understood, but it is believed to interfere with the function of macrophages and T cells, which play a crucial role in the immune response.

Administration and Dosage

Aurotioprol is typically administered via intramuscular injection. The dosage and frequency of administration depend on the severity of the disease and the patient's response to the treatment. Regular monitoring of blood and urine tests is required to detect any potential side effects.

Side Effects

Common side effects of aurotioprol include rash, stomatitis (inflammation of the mouth), and proteinuria (presence of excess proteins in the urine). More serious side effects can include bone marrow suppression, kidney damage, and hepatotoxicity (liver damage). Patients are advised to report any unusual symptoms to their healthcare provider immediately.

Contraindications

Aurotioprol is contraindicated in patients with a history of gold allergy, severe renal impairment, or significant liver disease. It should be used with caution in patients with a history of blood disorders.

History

The use of gold compounds in the treatment of rheumatoid arthritis dates back to the early 20th century. Aurotioprol is one of several gold-based drugs that have been developed for this purpose, along with aurothioglucose and auranofin.

See Also

• Rheumatoid arthritis
• Disease-modifying antirheumatic drugs
• Autoimmune diseases
• Gold compounds