CRSP3
(Redirected from Autosomal recessive nonsyndromic mental retardation-18)
Mediator of RNA polymerase II transcription subunit 23 is an enzyme that in humans is encoded by the MED23 gene.[1][2]
Function[edit | edit source]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]
Interactions[edit | edit source]
CRSP3 has been shown to interact with Estrogen receptor alpha,[3] CEBPB[4] and Cyclin-dependent kinase 8.[3][5]
References[edit | edit source]
External links[edit | edit source]
- Human MED23 genome location and MED23 gene details page in the UCSC Genome Browser.
Further reading[edit | edit source]
 | This article on a gene on human chromosome 6 is a stub. You can help WikiMD by expanding it. |
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Contributors: Prab R. Tumpati, MD
