B55
B55 is a protein that in humans is encoded by the PPP2R2B gene. This gene encodes a regulatory subunit of the protein phosphatase 2 (formerly named type 2A), a component of the protein kinase signaling pathway. This particular subunit has been shown to interact with and suppress the kinase activity of mitogen-activated protein kinase kinase kinase 1.
Function[edit | edit source]
The B55 protein is a regulatory subunit of the protein phosphatase 2, a key player in the protein kinase signaling pathway. It is involved in the regulation of various cellular processes, including cell division, gene expression, and development. The B55 protein interacts with and suppresses the kinase activity of mitogen-activated protein kinase kinase kinase 1, thereby playing a role in the regulation of cell growth and cell differentiation.
Clinical significance[edit | edit source]
Mutations in the PPP2R2B gene, which encodes the B55 protein, have been associated with Parkinson's disease, Alzheimer's disease, and other neurodegenerative diseases. Further research is needed to fully understand the role of this protein in these diseases and to develop potential therapeutic strategies.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- PPP2R2B at the National Center for Biotechnology Information
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Contributors: Prab R. Tumpati, MD
