BMP15

BMP15 or Bone Morphogenetic Protein 15 is a protein that in humans is encoded by the BMP15 gene. It is a member of the TGF-β superfamily, which is involved in the development of the ovary and the regulation of folliculogenesis.

Function

BMP15 is an oocyte-derived growth factor that controls the development and function of granulosa cells in the mammalian ovary. It is essential for female fertility, as mutations in the BMP15 gene can lead to premature ovarian failure (POF) and ovarian dysgenesis.

Clinical significance

Mutations in the BMP15 gene have been associated with ovarian dysgenesis 2, a condition that causes infertility in women. In addition, BMP15 mutations have been linked to hypergonadotropic ovarian failure, a condition characterized by a lack of ovulation and early menopause.

See also

• Bone morphogenetic protein
• Ovarian dysgenesis
• Premature ovarian failure

External links

• BMP15 at the US National Library of Medicine Medical Subject Headings (MeSH)

BMP15 Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski