BMS-345541

BMS-345541 is a highly selective inhibitor of IKK that is used in the research of various diseases. It is known for its ability to inhibit both IKK-α and IKK-β with an IC50 of 0.3 and 4 μM, respectively.

Mechanism of Action

BMS-345541 works by inhibiting the IκB kinase (IKK) complex, which plays a crucial role in the activation of the NF-κB pathway. This pathway is involved in the regulation of various cellular processes, including inflammation, immunity, cell proliferation, and survival. By inhibiting the IKK complex, BMS-345541 can effectively suppress the activation of the NF-κB pathway, thereby potentially influencing these cellular processes.

Applications in Research

BMS-345541 has been used in various research studies to investigate the role of the NF-κB pathway in different diseases. For instance, it has been used in studies on cancer, autoimmune diseases, and inflammatory diseases. In these studies, BMS-345541 has shown potential in inhibiting the growth of cancer cells, reducing inflammation, and modulating immune responses.

Potential Therapeutic Uses

While BMS-345541 is primarily used in research, its ability to inhibit the NF-κB pathway suggests potential therapeutic uses. For example, it could potentially be used in the treatment of diseases where the NF-κB pathway is overactive, such as certain types of cancer, autoimmune diseases, and inflammatory diseases. However, more research is needed to fully understand the potential therapeutic uses of BMS-345541.

Safety and Toxicity

The safety and toxicity of BMS-345541 are not fully understood, as it is primarily used in research settings. However, like all IKK inhibitors, it has the potential to cause side effects, particularly if used in high doses or for extended periods of time. These could potentially include liver damage, gastrointestinal issues, and immune system suppression.

See Also

• IKK
• NF-κB
• Cancer
• Autoimmune diseases
• Inflammatory diseases

References

BMS-345541 Resources
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