BPIFB1

BPIFB1 (BPI Fold Containing Family B Member 1) is a protein that in humans is encoded by the BPIFB1 gene. It is a member of the Bactericidal/permeability-increasing protein family and plays a significant role in the immune system.

Function

BPIFB1 is a secretory protein found in various tissues, including the lungs and salivary glands. It is involved in the body's defense against bacteria and other pathogens. The protein is believed to have antimicrobial activity and may play a role in host defense against bacteria.

Clinical significance

Alterations in the BPIFB1 gene have been associated with various diseases. For example, variations in this gene have been linked to cystic fibrosis, a genetic disorder that affects the lungs and digestive system. Additionally, BPIFB1 has been implicated in chronic obstructive pulmonary disease (COPD), a type of obstructive lung disease characterized by long-term breathing problems and poor airflow.

Research

Research into BPIFB1 is ongoing, with studies investigating its role in various diseases and its potential as a therapeutic target. For example, a study published in the American Journal of Respiratory and Critical Care Medicine found that BPIFB1 may play a role in the development of pulmonary fibrosis, a condition in which the lungs become scarred over time.

See also

• Bactericidal/permeability-increasing proteins
• Cystic fibrosis
• Chronic obstructive pulmonary disease

External links

• BPIFB1 at the National Center for Biotechnology Information