BST1

BST1 or Bone Marrow Stromal Antigen 1 is a protein that in humans is encoded by the BST1 gene. It is also known as CD157 and Bone Marrow Stromal Cell Antigen 1.

Function

BST1 is an enzyme that catalyzes the synthesis of cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. It is also involved in the mobilization of neutrophils. This protein is prominently expressed on the surface of bone marrow stromal cells, which is why it is often referred to as Bone Marrow Stromal Antigen 1.

Clinical Significance

Mutations in the BST1 gene have been associated with Parkinson's disease. Studies have shown that the BST1 gene may play a role in the pathogenesis of Parkinson's disease, although the exact mechanism is not yet fully understood.

Structure

The BST1 protein is a member of the ADP-ribosyl cyclase family. It has a molecular weight of approximately 42 kDa and is composed of 382 amino acids. The protein has two main domains: an extracellular domain and a transmembrane domain.

See Also

• ADP-ribosyl cyclase
• Parkinson's disease
• Bone marrow