Benzylthiouracil

Benzylthiouracil is a thioamide medication primarily used in the treatment of hyperthyroidism. It is a derivative of propylthiouracil and works by inhibiting the enzyme thyroid peroxidase, which plays a crucial role in the production of thyroid hormones.

Mechanism of Action

Benzylthiouracil, like other thioamides, inhibits the enzyme thyroid peroxidase. This enzyme is responsible for the iodination of tyrosine residues in thyroglobulin, a critical step in the synthesis of thyroid hormones triiodothyronine (T3) and thyroxine (T4). By inhibiting this enzyme, benzylthiouracil reduces the production of thyroid hormones, thereby reducing the symptoms of hyperthyroidism.

Clinical Use

Benzylthiouracil is used in the treatment of hyperthyroidism, a condition characterized by an overactive thyroid gland and excessive production of thyroid hormones. This can lead to symptoms such as rapid heart rate, weight loss, and anxiety. By reducing the production of thyroid hormones, benzylthiouracil can help to alleviate these symptoms.

Side Effects

Like other thioamides, benzylthiouracil can cause side effects. These may include skin rash, nausea, and liver damage. In rare cases, it can cause a severe decrease in white blood cells, a condition known as agranulocytosis. This can lead to serious infections and requires immediate medical attention.

Pharmacokinetics

Benzylthiouracil is absorbed from the gastrointestinal tract and is metabolized in the liver. It is excreted in the urine.

See Also

• Thioamide
• Hyperthyroidism
• Thyroid peroxidase
• Thyroid hormones

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• Benzylthiouracil