Bepridil hydrochloride
Bepridil hydrochloride is a calcium channel blocker used in the treatment of angina pectoris, a condition characterized by chest pain due to reduced blood flow to the heart. It is a non-selective calcium channel blocker, meaning it affects multiple types of calcium channels in the body. Bepridil hydrochloride is not commonly used due to its potential for serious side effects, including life-threatening heart rhythm disorders.
Pharmacology[edit | edit source]
Bepridil hydrochloride works by inhibiting the influx of calcium ions into cardiac and smooth muscle cells. This action relaxes the blood vessels, allowing blood to flow more easily and reducing the heart's workload. It also slows the electrical conduction in the heart, which can help control abnormal heart rhythms.
Clinical Use[edit | edit source]
Bepridil hydrochloride is used to treat angina pectoris, but it is typically reserved for patients who have not responded to other treatments due to its potential for serious side effects. It is taken orally, usually once a day.
Side Effects[edit | edit source]
The most common side effects of bepridil hydrochloride include nausea, dizziness, and headache. However, it can also cause more serious side effects, including life-threatening heart rhythm disorders. For this reason, it is typically reserved for use in patients who have not responded to other treatments.
History[edit | edit source]
Bepridil hydrochloride was first approved for use in the United States in 1984. However, it was withdrawn from the market in 1998 due to concerns about its safety profile.
See Also[edit | edit source]
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