Beta1-adrenergic agonist
Beta1-adrenergic agonist is a type of pharmacological agent that acts upon the beta1-adrenergic receptor, a type of G protein-coupled receptor found primarily in the heart and kidneys. These agents are used in the treatment of various cardiovascular conditions, including heart failure, angina pectoris, and hypertension.
Mechanism of Action[edit | edit source]
Beta1-adrenergic agonists work by stimulating the beta1-adrenergic receptors, which are part of the sympathetic nervous system. When these receptors are activated, they increase the heart rate and force of contraction, thereby increasing cardiac output. This can help to improve blood flow and oxygen delivery to the body's tissues.
Therapeutic Uses[edit | edit source]
Beta1-adrenergic agonists are used in the management of several cardiovascular conditions. In heart failure, they can help to increase cardiac output and improve symptoms. In angina pectoris, they can help to reduce the frequency and severity of angina attacks. In hypertension, they can help to lower blood pressure.
Side Effects[edit | edit source]
Like all medications, beta1-adrenergic agonists can cause side effects. These may include tachycardia (rapid heart rate), palpitations, anxiety, and insomnia. In some cases, they may also cause cardiac arrhythmias (irregular heart rhythms).
Examples[edit | edit source]
Examples of beta1-adrenergic agonists include dobutamine, which is used in the treatment of heart failure, and isoproterenol, which is used in the treatment of bradycardia (slow heart rate) and heart block.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD