Betamipron

Betamipron

Betamipron is a chemical compound used in combination with Piperacillin to inhibit the renal excretion of Piperacillin. It is a non-sulfonamide compound, which differentiates it from most other beta-lactamase inhibitors.

Chemistry

Betamipron is a white crystalline powder with the chemical formula C16H24N2O4. It is soluble in water and slightly soluble in ethanol. The compound is a non-sulfonamide beta-lactamase inhibitor, which means it does not contain the sulfonamide functional group that is common in other beta-lactamase inhibitors.

Pharmacology

In the body, Betamipron acts as a competitive inhibitor of the renal tubular secretion of Piperacillin. This means it competes with Piperacillin for the same transport mechanism in the kidneys, resulting in a decrease in the renal clearance of Piperacillin. This allows for higher concentrations of Piperacillin to remain in the body for a longer period of time, increasing its effectiveness.

Clinical Use

Betamipron is not used on its own, but rather in combination with Piperacillin. This combination is used to treat a variety of bacterial infections, including those caused by Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae. The addition of Betamipron to Piperacillin therapy increases the effectiveness of the treatment by allowing for higher and more sustained concentrations of Piperacillin in the body.

Side Effects

As with any medication, the use of Betamipron can result in side effects. These can include nausea, vomiting, diarrhea, and rash. In rare cases, more serious side effects such as anaphylaxis can occur.

See Also

• Piperacillin
• Beta-lactamase inhibitor
• Renal tubular secretion