Epoetin beta

Epoetin beta is a synthetic, recombinant form of erythropoietin, a hormone naturally produced by the kidneys that stimulates the production of red blood cells. It is used in the treatment of anemia associated with chronic renal failure and in cancer patients receiving chemotherapy.

History

Epoetin beta was developed in the late 1980s as a result of advances in recombinant DNA technology. It was first approved for medical use in the European Union in 1997.

Medical uses

Epoetin beta is used to treat anemia in patients with chronic kidney disease, both those who are on dialysis and those who are not. It is also used to treat anemia in cancer patients receiving chemotherapy, and in patients undergoing major surgery to reduce the need for blood transfusions.

Mechanism of action

Epoetin beta works by stimulating the bone marrow to produce more red blood cells, thereby increasing the oxygen-carrying capacity of the blood. It binds to the erythropoietin receptor on the surface of red blood cell precursors in the bone marrow, triggering their maturation into functional red blood cells.

Side effects

Common side effects of epoetin beta include headache, hypertension, and flu-like symptoms. Serious side effects can include blood clots, heart attack, stroke, and increased tumor growth in cancer patients.

See also

• Erythropoiesis-stimulating agent
• Anemia
• Chronic kidney disease
• Chemotherapy