Betazole hydrochloride
Detailed article on Betazole hydrochloride
Betazole hydrochloride is a histamine H2 receptor agonist used primarily in the diagnosis of gastric acid secretory function. It is a derivative of histamine and is known for its ability to stimulate gastric acid secretion.
Pharmacology[edit | edit source]
Mechanism of Action[edit | edit source]
Betazole hydrochloride acts as an agonist at the H2 receptors located on the parietal cells of the stomach. By binding to these receptors, betazole stimulates the secretion of gastric acid. This action is similar to that of histamine, but betazole is more selective for the H2 receptor, making it useful in diagnostic tests.
Pharmacokinetics[edit | edit source]
The pharmacokinetics of betazole hydrochloride involve its absorption, distribution, metabolism, and excretion. Upon administration, betazole is absorbed and distributed throughout the body. It is metabolized primarily in the liver and excreted via the kidneys. The elimination half-life of betazole is relatively short, which is suitable for its use in diagnostic procedures.
Clinical Use[edit | edit source]
Diagnostic Testing[edit | edit source]
Betazole hydrochloride is used in the diagnosis of gastric acid secretory function. It is administered to stimulate gastric acid secretion, and the response is measured to assess the functional capacity of the gastric parietal cells. This test can help diagnose conditions such as Zollinger-Ellison syndrome and achlorhydria.
Procedure[edit | edit source]
In a typical diagnostic procedure, betazole hydrochloride is administered intravenously. Gastric acid secretion is then measured over a specified period. The results are compared to normal values to determine if there is an abnormality in acid secretion.
Side Effects[edit | edit source]
The administration of betazole hydrochloride can lead to side effects similar to those of histamine, including flushing, headache, and hypotension. These effects are generally mild and transient.
Contraindications[edit | edit source]
Betazole hydrochloride should not be used in patients with known hypersensitivity to the drug or its components. Caution is advised in patients with asthma or peptic ulcer disease, as the stimulation of gastric acid secretion can exacerbate these conditions.
See Also[edit | edit source]
External Links[edit | edit source]
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