Bezafibrate
A lipid-lowering medication
Bezafibrate | |
---|---|
![]() | |
INN | |
Drug class | |
Routes of administration | |
Pregnancy category | |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Legal status | |
CAS Number | |
PubChem | |
DrugBank | |
ChemSpider | |
KEGG |
Bezafibrate is a fibrate medication used to treat hyperlipidemia, a condition characterized by elevated levels of lipids in the blood. It is primarily used to lower cholesterol and triglyceride levels, thereby reducing the risk of cardiovascular disease.
Mechanism of Action[edit | edit source]
Bezafibrate works by activating peroxisome proliferator-activated receptors (PPARs), which are nuclear receptors that regulate the expression of genes involved in lipid metabolism. By activating PPARs, bezafibrate increases the oxidation of fatty acids and enhances the clearance of triglycerides from the bloodstream. This leads to a reduction in very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) levels, while increasing high-density lipoprotein (HDL) levels.
Clinical Uses[edit | edit source]
Bezafibrate is indicated for the treatment of various forms of hyperlipidemia, including:
- Hypercholesterolemia
- Hypertriglyceridemia
- Mixed hyperlipidemia
It is often prescribed when dietary measures and other non-pharmacological interventions have failed to adequately control lipid levels.
Side Effects[edit | edit source]
Common side effects of bezafibrate include gastrointestinal disturbances such as nausea, diarrhea, and abdominal pain. Other potential side effects include:
- Myopathy
- Liver enzyme abnormalities
- Gallstones
Patients are advised to report any unexplained muscle pain or weakness, as this could indicate a serious condition known as rhabdomyolysis.
Contraindications[edit | edit source]
Bezafibrate is contraindicated in patients with:
- Severe liver disease
- Severe renal impairment
- Pre-existing gallbladder disease
Drug Interactions[edit | edit source]
Bezafibrate may interact with other medications, including:
- Statins: Increased risk of myopathy and rhabdomyolysis
- Anticoagulants: Enhanced anticoagulant effect
Synthesis[edit | edit source]
The synthesis of bezafibrate involves the reaction of 4-chlorobenzoyl chloride with 2-(4-hydroxyphenyl)ethylamine to form an amide intermediate. This intermediate is then reacted with 2-bromo-2-methylpropanoic acid to yield bezafibrate.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD