Very-low-density lipoprotein
Very-low-density lipoprotein (VLDL) is a type of lipoprotein made by the liver. VLDL is one of the five major groups of lipoproteins (chylomicrons, VLDL, LDL, IDL, and HDL) that enable fats and cholesterol to move within the water-based solution of the bloodstream.
Structure[edit | edit source]
VLDL particles are assembled in the liver from triglycerides, cholesterol, and apolipoproteins. VLDL particles are released from the liver into the bloodstream to supply body tissues with a type of fat, known as triglycerides.
Function[edit | edit source]
VLDL transports endogenous triglycerides, phospholipids, cholesterol, and cholesteryl esters. It functions as the body's internal transport mechanism for lipids and is responsible for the distribution of triglycerides to cells in the body.
Clinical significance[edit | edit source]
High levels of VLDL cholesterol have been associated with the development of atherosclerosis, which can lead to diseases such as coronary artery disease and stroke. VLDL levels are often high in people with obesity, metabolic syndrome, and Type 2 diabetes.
See also[edit | edit source]
- Cholesterol
- Lipoprotein
- Atherosclerosis
- Coronary artery disease
- Stroke
- Obesity
- Metabolic syndrome
- Type 2 diabetes
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Contributors: Prab R. Tumpati, MD
