Bismuth subcitrate

Bismuth Subcitrate is a chemical compound used in medicine, specifically in the treatment of peptic ulcer disease and Helicobacter pylori infection. It is also known as colloidal bismuth subcitrate (CBS) and De-Nol.

Chemical Properties

Bismuth subcitrate is a complex of bismuth and citrate ions. It is a white or almost white powder that is soluble in water. The chemical formula for bismuth subcitrate is C12H10Bi2O14.

Medical Uses

Bismuth subcitrate is used in the treatment of peptic ulcer disease and Helicobacter pylori infection. It works by coating the ulcer and protecting it from stomach acid. Bismuth subcitrate also has antimicrobial properties that help to kill Helicobacter pylori bacteria.

Side Effects

Common side effects of bismuth subcitrate include nausea, vomiting, and dark stools. In rare cases, it can cause a black tongue and black stools. Long-term use of bismuth subcitrate can lead to bismuth toxicity, which can cause symptoms such as skin reactions, neurologic abnormalities, and kidney damage.

Pharmacology

Bismuth subcitrate is not absorbed into the systemic circulation to a significant extent, which means that it has a low risk of systemic toxicity. It is excreted primarily in the feces.

History

Bismuth subcitrate was first used in medicine in the 18th century. It was originally used as a treatment for syphilis, but it is now primarily used in the treatment of peptic ulcer disease and Helicobacter pylori infection.

See Also

• Peptic ulcer disease
• Helicobacter pylori
• Bismuth