Breslow's depth

Breslow's depth is a measure used in the field of oncology to describe the depth of invasion of melanoma, a type of skin cancer. Named after Alexander Breslow, a pathologist, it is a strong predictor of the patient's prognosis.

Overview

Breslow's depth is measured from the granular layer of the epidermis down to the deepest point of invasion (sometimes into the subcutaneous fat). The depth is typically measured in millimeters and is used to stage the cancer, with higher numbers indicating a deeper invasion and a worse prognosis.

Measurement

The measurement of Breslow's depth is done under a microscope by a pathologist. The pathologist measures the tumor from the base to the surface of the skin. The measurement is taken from the granular layer of the epidermis to the deepest point of invasion.

Staging

Breslow's depth is used in conjunction with Clark's level to stage melanoma. The depth is divided into four stages:

• Less than 1.00 mm is considered thin melanoma
• 1.01 to 2.00 mm is intermediate thickness
• 2.01 to 4.00 mm is considered thick melanoma
• Greater than 4.00 mm is considered very thick melanoma

Prognosis

The prognosis of melanoma is strongly related to Breslow's depth. A higher Breslow's depth indicates a deeper invasion into the skin and a worse prognosis. The five-year survival rate decreases as the Breslow's depth increases.

See also

• Melanoma
• Skin cancer
• Oncology
• Pathology
• Alexander Breslow
• Clark's level