Brifentanil

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Brifentanil

Brifentanil is a potent opioid analgesic that is an analog of fentanyl. It is most commonly used in the practice of anesthesia and is typically administered intravenously. It is also used for pain management in certain situations. Brifentanil is approximately 81 times more potent than fentanyl, making it one of the most potent opioids available.

Chemistry

Brifentanil, like other opioids, is a synthetic compound. It is part of the 4-anilidopiperidine class of opioids and is structurally related to fentanyl. Brifentanil is a N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl) propanamide, with a molecular formula of C23H30N2O.

Pharmacology

Brifentanil acts primarily on the mu-opioid receptor. It exerts its analgesic effects by mimicking the actions of endogenous peptides at mu-opioid receptors in the brain. This leads to an alteration in the perception of pain.

The onset of action of brifentanil is rapid, and its duration of action is relatively short due to its rapid metabolism and clearance. This makes it particularly useful in situations where rapid onset and offset of analgesia are required.

Side Effects

Like all opioids, brifentanil has a range of side effects. The most common of these are nausea, vomiting, constipation, and drowsiness. More serious side effects can include respiratory depression, which can be life-threatening.

Legal Status

Brifentanil is a controlled substance and is classified as a Schedule II drug under the Controlled Substances Act in the United States. This means it has a high potential for abuse and dependence.

See Also

• Fentanyl
• Opioid
• Anesthesia
• Controlled Substances Act