Brincidofovir
An antiviral medication used to treat certain viral infections
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Brincidofovir is an antiviral drug that is used to treat certain viral infections. It is a lipid conjugate of cidofovir, designed to improve the delivery and efficacy of the drug while reducing its toxicity.
Mechanism of Action[edit | edit source]
Brincidofovir works by inhibiting viral DNA polymerase, an enzyme critical for viral DNA replication. By blocking this enzyme, brincidofovir prevents the virus from multiplying and spreading within the host organism.
Clinical Uses[edit | edit source]
Brincidofovir is primarily used in the treatment of infections caused by double-stranded DNA viruses, including:
It is particularly useful in immunocompromised patients, such as those undergoing hematopoietic stem cell transplantation.
Pharmacokinetics[edit | edit source]
Brincidofovir is administered orally and is absorbed into the bloodstream, where it is converted into its active form. The lipid conjugation allows for better cellular uptake and distribution, enhancing its antiviral activity while minimizing renal toxicity, a common side effect associated with cidofovir.
Side Effects[edit | edit source]
Common side effects of brincidofovir include:
Less common but serious side effects can include liver enzyme abnormalities and gastrointestinal disturbances.
Development and Approval[edit | edit source]
Brincidofovir was developed by Chimerix, a biopharmaceutical company. It has undergone various clinical trials to assess its efficacy and safety in treating viral infections. The drug has been granted orphan drug status for certain indications, reflecting its importance in treating rare conditions.
Related pages[edit | edit source]
Brincidofovir
Brincidofovir
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