Brodmann area 49

Brodmann area 49 (BA49) is a region in the brain that is part of the prefrontal cortex. It is located in the frontal lobe and is involved in various cognitive functions, including memory, attention, and decision making.

Anatomy

BA49 is located in the ventromedial prefrontal cortex (vmPFC), which is situated in the lower part of the frontal lobe. It is bordered by Brodmann area 10 (BA10) anteriorly, Brodmann area 11 (BA11) laterally, and Brodmann area 25 (BA25) posteriorly.

Location of Brodmann area 49 in the human brain.

Function

The exact functions of BA49 are still under investigation, but it is believed to play a role in various cognitive processes. Studies have suggested that it is involved in working memory, attention, decision making, and emotion regulation. It is also thought to contribute to social cognition, which involves understanding and interpreting the behavior of others.

Clinical significance

Alterations in BA49 have been associated with various neurological and psychiatric disorders. For example, reduced volume and activity in this area have been observed in patients with schizophrenia and major depressive disorder. Moreover, damage to BA49 can result in cognitive impairment, including difficulties with memory, attention, and decision making.

See also

• Brodmann area
• Prefrontal cortex
• Frontal lobe