Bruch's membrane

Bruch's membrane (also known as the basilar membrane) is an important part of the eye that plays a crucial role in the functioning of the retina. It is a thin, five-layered structure located between the choroid and the retina.

Structure[edit | edit source]

Bruch's membrane is composed of five distinct layers. From innermost to outermost, these layers are:

The basement membrane of the retinal pigment epithelium (RPE)
The inner collagenous layer
The elastic layer
The outer collagenous layer
The basement membrane of the choroid

Each layer has a specific function and contributes to the overall role of Bruch's membrane in the eye.

Function[edit | edit source]

Bruch's membrane serves several important functions in the eye. It acts as a physical barrier, preventing the entry of large molecules and cells into the retina. It also plays a role in the transport of nutrients, waste products, and ions between the choroid and the retina. Additionally, Bruch's membrane provides structural support to the retina and the choroid.

Clinical significance[edit | edit source]

Damage or changes to Bruch's membrane can lead to a number of eye conditions. For example, Age-related macular degeneration (AMD), a leading cause of vision loss in older adults, is associated with changes in Bruch's membrane. Other conditions that can be linked to changes in Bruch's membrane include choroidal neovascularization and central serous retinopathy.

References[edit | edit source]

Bruch's membrane Resources
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