Bulbocapnine

Bulbocapnine is an alkaloid found in several varieties of plants, including Corydalis and Dicentra, plants that belong to the family Papaveraceae. It is known to cause a temporary paralysis of motor function and has been used in the past as a muscle relaxant. However, its use has been largely discontinued due to the availability of safer alternatives.

Chemistry[edit | edit source]

Bulbocapnine is a member of the benzylisoquinoline class of alkaloids. It is structurally similar to other alkaloids in this class, such as papaverine and morphine. The compound is composed of a benzylisoquinoline backbone with a methylenedioxy group and a dimethoxy group attached.

Pharmacology[edit | edit source]

The exact mechanism of action of bulbocapnine is not well understood. It is known to act as a dopamine antagonist, blocking the action of dopamine in the brain. This can lead to a variety of effects, including motor paralysis, sedation, and hypotension. However, the compound is also known to have a high toxicity, which has limited its use in medicine.

Medical Use[edit | edit source]

Historically, bulbocapnine was used as a muscle relaxant and as a treatment for Parkinson's disease. However, due to its high toxicity and the availability of safer alternatives, it is no longer used for these purposes.

Toxicity[edit | edit source]

Bulbocapnine is known to be highly toxic. Symptoms of bulbocapnine poisoning can include motor paralysis, sedation, and hypotension. In severe cases, it can lead to respiratory failure and death.

See Also[edit | edit source]

Bulbocapnine Resources
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