Bunaftine

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An overview of the antifungal medication Bunaftine


Bunaftine
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Bunaftine is an antifungal medication used primarily in the treatment of dermatophytosis, a type of fungal infection affecting the skin, hair, and nails. It belongs to the class of allylamine antifungals, which work by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.

Mechanism of Action[edit | edit source]

Bunaftine functions by targeting the squalene epoxidase enzyme, which is crucial in the biosynthesis of ergosterol. By inhibiting this enzyme, Bunaftine disrupts the formation of the fungal cell membrane, leading to increased membrane permeability and ultimately causing cell death. This mechanism is similar to other allylamine antifungals such as terbinafine.

Pharmacokinetics[edit | edit source]

Bunaftine is administered topically, allowing it to concentrate at the site of infection. The absorption of Bunaftine through the skin is minimal, which reduces the risk of systemic side effects. The drug is metabolized in the liver and excreted primarily through the urine.

Clinical Uses[edit | edit source]

Bunaftine is indicated for the treatment of various dermatophytic infections, including:

Side Effects[edit | edit source]

Common side effects of Bunaftine include local irritation, redness, and itching at the site of application. Rarely, patients may experience allergic reactions such as rash or swelling. It is important to discontinue use and seek medical advice if severe reactions occur.

Contraindications[edit | edit source]

Bunaftine should not be used in individuals with known hypersensitivity to allylamine antifungals. Caution is advised in patients with liver disease due to the drug's hepatic metabolism.

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