Butirosin

Butirosin is an aminoglycoside antibiotic that is derived from the bacterium Bacillus circulans. It is composed of two components, Butirosin A and Butirosin B, both of which have antibacterial properties.

History[edit | edit source]

Butirosin was first isolated in 1966 from Bacillus circulans strains found in soil samples. The discovery of this antibiotic was significant as it provided a new treatment option for infections caused by Gram-negative bacteria.

Mechanism of Action[edit | edit source]

Like other aminoglycosides, Butirosin works by binding to the 30S subunit of the bacterial ribosome, inhibiting protein synthesis and leading to cell death. This makes it effective against a wide range of bacteria, including many that are resistant to other antibiotics.

Medical Uses[edit | edit source]

Butirosin is used to treat a variety of bacterial infections, particularly those caused by Gram-negative bacteria. These include infections of the urinary tract, respiratory tract, skin, and soft tissues. It is also used in combination with other antibiotics to treat severe or life-threatening infections.

Side Effects[edit | edit source]

As with all antibiotics, Butirosin can cause side effects. These may include kidney damage, hearing loss, and allergic reactions. Patients should be monitored closely for these effects while taking Butirosin.

Resistance[edit | edit source]

Bacterial resistance to Butirosin is a growing concern. This resistance can occur through several mechanisms, including modification of the antibiotic, alteration of the target site, or increased efflux of the drug from the bacterial cell.

References[edit | edit source]

Butirosin Resources
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