C-Met

C-Met is a protein encoded by the MET gene in humans. It is a receptor tyrosine kinase that is involved in cell growth and differentiation, cell migration, and also in cell scattering. C-Met is also known as HGFR, hepatocyte growth factor receptor.

Function

C-Met is essential for embryonic development, organogenesis and wound healing. The binding of its ligand, Hepatocyte Growth Factor (HGF), triggers a series of biochemical reactions that lead to mitogenesis, motogenesis and morphogenesis.

Clinical Significance

Abnormal activation of the C-Met pathway has been found in several types of tumors, which can result in invasive growth and metastasis. Inhibitors of C-Met are therefore considered to have potential as cancer therapeutics.

Structure

The MET gene encodes a protein that is a member of the receptor tyrosine kinase family. The encoded protein contains a sema domain in its extracellular region, a transmembrane domain, and a tyrosine kinase domain in its cytoplasmic region.

See Also

• Hepatocyte Growth Factor
• Receptor Tyrosine Kinase
• Cancer Therapeutics

References

C-Met Resources
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