CAMP responsive element modulator
CAMP responsive element modulator (CREM) is a protein that in humans is encoded by the CREM gene. CREM is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome.
Function[edit | edit source]
The CREM gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
Clinical significance[edit | edit source]
Alterations in CREM gene function can lead to various medical conditions. For instance, mutations in this gene have been associated with major depressive disorders and autoimmune diseases.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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