CARD14

CARD14 (Caspase Recruitment Domain Family Member 14) is a protein that in humans is encoded by the CARD14 gene. It is a member of the caspase recruitment domain-containing (CARD) family of proteins, which are involved in a variety of processes including inflammation and apoptosis.

Function

CARD14 is a protein-coding gene that is part of the CARD protein family. These proteins play a crucial role in apoptosis (programmed cell death) and inflammation. CARD14, in particular, is known to induce NF-kappaB activation, a protein complex that controls DNA transcription, cytokine production, and cell survival.

Clinical significance

Mutations in the CARD14 gene have been associated with psoriasis, a chronic skin condition, and pityriasis rubra pilaris, a rare skin disorder. The exact mechanism by which these mutations lead to skin disorders is not fully understood, but it is believed that they result in an overactive inflammatory response.

Research

Research into CARD14 is ongoing, with scientists seeking to better understand its role in inflammation and cell death, as well as its potential as a therapeutic target for inflammatory diseases and cancer.

See also

• Caspase
• Apoptosis
• Inflammation
• Psoriasis
• Pityriasis rubra pilaris

References

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