CCL27

CCL27 (Chemokine (C-C motif) ligand 27) is a small cytokine belonging to the CC chemokine family that is also known as Cutaneous T-cell-attracting chemokine (CTACK). It is expressed in the skin and selectively attracts skin-homing memory T cells via the chemokine receptor CCR10.

Function

CCL27 is secreted by keratinocytes, and its expression is upregulated by inflammatory signals. It plays a crucial role in the migration of T cells to the skin during inflammatory responses. CCL27 and its receptor CCR10 are essential for the regulation of the immune system's response to cutaneous infections.

Clinical significance

Alterations in the expression of CCL27 have been associated with various skin diseases, including psoriasis, atopic dermatitis, and cutaneous T cell lymphoma. In these conditions, the overexpression of CCL27 leads to an excessive accumulation of T cells in the skin, resulting in inflammation and skin damage.

Research

Research on CCL27 has focused on its potential as a therapeutic target for inflammatory skin diseases. Inhibiting the interaction between CCL27 and CCR10 could potentially reduce inflammation and improve skin conditions.

See also

• Chemokine
• Cytokine
• T cell
• Keratinocyte
• Psoriasis
• Atopic dermatitis
• Cutaneous T cell lymphoma

References

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