CCR10
CCR10 is a chemokine receptor that plays a significant role in the immune system. It is a member of the G protein-coupled receptor (GPCR) family and is primarily involved in the regulation of leukocyte trafficking. CCR10 is known to bind to the chemokines CCL27 and CCL28, which are crucial for the migration of T cells and other immune cells to specific tissues.
Structure[edit | edit source]
CCR10 is a seven-transmembrane receptor, characteristic of the GPCR family. It is encoded by the CCR10 gene located on chromosome 17 in humans. The receptor consists of an extracellular N-terminus, seven transmembrane helices, and an intracellular C-terminus.
Function[edit | edit source]
CCR10 is predominantly expressed in skin and mucosal tissues, where it mediates the homing of immune cells to these areas. The interaction between CCR10 and its ligands, CCL27 and CCL28, is essential for the immune surveillance and inflammatory responses in these tissues. This receptor-ligand interaction is particularly important in the context of skin diseases such as psoriasis and atopic dermatitis.
Ligands[edit | edit source]
- CCL27: Also known as cutaneous T-cell-attracting chemokine (CTACK), it is primarily expressed in the skin.
- CCL28: Also known as mucosa-associated epithelial chemokine (MEC), it is expressed in various mucosal tissues.
Clinical Significance[edit | edit source]
CCR10 and its ligands are implicated in several inflammatory diseases and autoimmune disorders. The receptor is a potential target for therapeutic interventions aimed at modulating immune cell trafficking to treat conditions such as psoriasis, atopic dermatitis, and other chronic inflammatory diseases.
Research[edit | edit source]
Ongoing research is focused on understanding the precise mechanisms by which CCR10 regulates immune cell migration and its role in various diseases. Studies are also exploring the potential of CCR10 as a therapeutic target for modulating immune responses in autoimmune diseases and cancer.
Related Pages[edit | edit source]
- Chemokine receptor
- G protein-coupled receptor
- CCL27
- CCL28
- Psoriasis
- Atopic dermatitis
- Autoimmune disease
- Inflammatory disease
 | This article about a biochemical receptor is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
