CCPA (biochemistry)

CCPA (biochemistry) is a potent and selective adenosine A1 receptor antagonist. It is often used in scientific research to understand the role of A1 receptors in the body. CCPA stands for 2-chloro-N6-cyclopentyladenosine.

Chemistry

CCPA is a derivative of adenosine, a nucleoside that plays crucial roles in biochemical processes like protein synthesis and cellular energy transfer. It is chemically synthesized by introducing a chloro group at the 2 position and a cyclopentyl group at the N6 position of the adenosine molecule.

Pharmacology

CCPA acts by binding to the adenosine A1 receptor and blocking its activation by adenosine. This makes it an antagonist of the receptor. The adenosine A1 receptor is one of the four subtypes of adenosine receptors (A1, A2A, A2B, and A3) in the body. It is widely distributed in the brain, heart, and other tissues.

Uses in Research

CCPA is primarily used in research to study the functions of the adenosine A1 receptor. By blocking the receptor, researchers can investigate what happens when it is not activated. This can provide insights into the physiological and pathological roles of the receptor.

Safety and Toxicity

As a research chemical, CCPA is not intended for human consumption. Its safety and toxicity in humans have not been thoroughly studied. Therefore, it should be handled with care in the laboratory.

See Also

• Adenosine receptor
• Adenosine
• Receptor antagonist