CCR11

CCR11 is a G protein-coupled receptor that in humans is encoded by the CCR11 gene. It is also known as Chemokine (C-C motif) receptor 11.

Function

CCR11 is a receptor for a C-C type chemokine. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Gene

The CCR11 gene is located on the long (q) arm of chromosome 3 at position 21.3, from base pair 45,550,001 to base pair 45,560,000.

Clinical significance

CCR11 has been studied in the context of asthma, allergy, and inflammatory diseases. It is thought to be involved in the inflammatory response of these conditions.

See also

• Chemokine receptor
• Chemokine
• G protein-coupled receptor

External links

• NCBI Gene

CCR11 Resources
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