CCR6

CCR6 is a gene that in humans is encoded by the CCR6 protein. This gene is a member of the Beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and B cells, and is known to be important in the immune system.

Function

CCR6 is a receptor for the chemokine CCL20 (also known as MIP-3 alpha), and can bind to this chemokine in a specific and high affinity manner. This receptor is expressed in the lymph nodes and peripheral blood leukocytes, and is particularly abundant in T cells. It has been shown to be important in B cell migration into B cell follicles of Peyer's patches and mesenteric lymph nodes. CCR6 is also involved in the trafficking of dendritic cells and T lymphocytes to inflamed tissues and lymphoid organs, playing a crucial role in the regulation of immune responses.

Clinical significance

Alterations in the function of CCR6 have been associated with various diseases, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. In addition, CCR6 has been implicated in the progression of certain types of cancer, such as colorectal cancer and breast cancer, as it can promote the migration and invasion of cancer cells.

See also

• Chemokine receptor
• Cluster of differentiation

External links

• CCR6 at the US National Library of Medicine Medical Subject Headings (MeSH)

CCR6 Resources
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