CCR8

CCR8 is a gene that encodes the Chemokine receptor CCR8 in humans. It is also known as CKRL1 or CMKBR8. The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is a receptor for the Chemokine CCL1. It has been shown to be involved in immune responses and may also play a role in inflammatory responses.

Function

The CCR8 gene encodes a protein that is a member of the G protein-coupled receptor family. This protein is a receptor for the chemokine CCL1. The encoded protein has been shown to bind to CCL1 and to mediate its effects. The effects of CCL1 include the attraction of T cells and the promotion of T cell survival. This makes the CCR8 protein an important part of the immune response.

Clinical significance

Alterations in the CCR8 gene have been associated with various diseases. For example, increased expression of CCR8 has been observed in Atopic dermatitis, a type of inflammatory skin disease. In addition, CCR8 has been implicated in the pathogenesis of HIV infection. The CCR8 protein is thought to play a role in the migration of HIV-infected cells to the brain, contributing to the development of neurological disorders associated with HIV infection.

See also

• Chemokine receptor
• G protein-coupled receptor
• Chemokine
• T cell
• Atopic dermatitis
• HIV

References

CCR8 Resources
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