CCR8
CCR8 is a gene that encodes the Chemokine receptor CCR8 in humans. It is also known as CKRL1 or CMKBR8. The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is a receptor for the Chemokine CCL1. It has been shown to be involved in immune responses and may also play a role in inflammatory responses.
Function[edit | edit source]
The CCR8 gene encodes a protein that is a member of the G protein-coupled receptor family. This protein is a receptor for the chemokine CCL1. The encoded protein has been shown to bind to CCL1 and to mediate its effects. The effects of CCL1 include the attraction of T cells and the promotion of T cell survival. This makes the CCR8 protein an important part of the immune response.
Clinical significance[edit | edit source]
Alterations in the CCR8 gene have been associated with various diseases. For example, increased expression of CCR8 has been observed in Atopic dermatitis, a type of inflammatory skin disease. In addition, CCR8 has been implicated in the pathogenesis of HIV infection. The CCR8 protein is thought to play a role in the migration of HIV-infected cells to the brain, contributing to the development of neurological disorders associated with HIV infection.
See also[edit | edit source]
References[edit | edit source]
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